Company: Applied Biomath
Job title: Sr. Director of Scientific Collaborations and Fellow of Modeling & Simulation
Alison recently joined Applied Biomath as Sr. Director of Scientific Collaborations and Fellow of Modeling & Simulation. Here she is part of the Business Development team providing scientific support and partner alignment based on her vast modeling experience in industry. Prior to joining Applied Biomath, Alison had an extensive modeling career at Pfizer, across many therapeutic domains. Most recently, she was modeling and simulation (M&S) lead supporting the Oncology Research Unit. In this role she led a team responsible for using M&S strategies to answer mechanistic questions, validate targets, select optimal compounds and translate to the clinic. Alison specializes in M&S of novel biotherapeutic modalities including bi-specific T-cell retargeting molecules, CAR-T cells, targeted nanoparticles and drug conjugates for treatment of cancer.
Use of Quantitative Systems Pharmacology (QSP) Modeling to Drive Decision Making of T Cell Engager mAbs from Target Identification to Phase 1 10:00 am
Target feasibility and selection Optimising drug format and Kds – impact on therapeutic window between low and high expressing cells Translation from in vitro to in vivo data to the clinic Predicting clinical starting and efficacious dosesRead more
day: Day Two