Michael Hedvat

Michael Hedvat

Company: Xencor

Job title: Associate Director

Seminars:

Live Q&A – Ask our Speakers Your Burning Questions 3:20 pm

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day: Day One

Tumor-Targeted CD28 Costimulatory Bispecific Antibodies Enhance T-Cell Activation in Solid Tumors 2:55 pm

• Antigen presenting cells typically provide T-cell costimulation by providing CD28 ligands during T-cell priming • We hypothesized that additional CD28 signaling at the T-cell: tumor cell interface could be beneficial • We designed B7H3 x CD28 and PDL1 x CD28 bispecific antibodies that conditionally costimulate CD28 only in the presence of their respective targets…Read more

day: Day One

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