Dual-Antigen Targeting & Co-Stimulation to Overcome Resistance & Antigen-Escape in Next Generation Multi- Specifics
- Translating the success of CD19/CD20 bispecific T-cell engager space by targeting two tumor-associated antigens simultaneously to ensure efficacy event when one antigen is downregulated
- Discussing strategies for incorporating co-stimulatory domains into multi-specific designs to enhance the depth and durability of clinical responses beyond what is possible with CD3 engagement alone
- Addressing the structural hurdles of trispecific and multispecific molecules whilst maintaining manufacturability and acceptable cost of goods