Engineering Co-Stimulation for Mitigating Systemic Toxicity & Maximising Localized T-Cell Activation
- Evaluating risk-benefit profile associated with systemic costimulatory receptor engagement
- Analyzing molecular design where co-stimulatory activation depends on signal 1 engagement to ensure T-cell proliferation is restricted to the tumor antigen surface
- Examining how tumor associated antigen effects efficacy and cytokine release