Join this workshop to master the structural complexity of next generation multispecifics, where the focus shifts from simple binding to the precise spatial coordination of the immunological synapse.

• Designing trispecifics that require two tumor antigens to trigger engagement, widening the therapeutic window
• Engineering trispecifics that require two different tumor antigens to trigger CD3 engagement, significantly widening the therapeutic index for antigens
• Overcoming engineering hurdles to ensure the two components of the TCE only meet on the tumor cell surface
• Technical deep-dive into target identification using TCR-target discovery engines to reduce minimal off-target reactivity
• Identifying the optimal inter-membrane distance and how the choice of epitopes on the tumor antigen dictates efficacy