PRO‑XTEN Masked T-Cell Engagers; A Novel Therapeutic Approach Enabling Protease‑Specific Activation of TCEs Only in the Tumor Microenvironment to Mitigate Damage to Healthy Tissues & Reduce Toxicity
- Exploring how engineering TCEs with protease-cleavable masks creates a molecular switch
- Discussing the protein engineering strategies at optimal masking architectures for TCEs
- Evaluating data on current clinical molecules using masking features and their potential to safely target high-expression antigens