Genevieve Desjardins
Principal Scientist - Protein Engineering Zymeworks
Seminars
Thursday 25th June 2026
Enhancing Efficacy of T-Cell Engagers in Solid Tumors with CD28 Co-Stimulation
2:00 pm
- CD28 stimulation has the potential to provide more durable responses and activate T cell responses in cold tumors with low T cell infiltration.
- ZW209 is a DLL3-targeted multispecific T cell engagers leveraging cis co-stimulation of CD28 with favorable preclinical efficacy and tolerability.
- Our conditional CD28 co-stimulation platform can be combined with multiple geometries and tumor associated antigens to increase efficacy of T cell engagers in both solid and liquid tumors.
