Developing Precision-Activated T-Cell Engagers to Improve Specificity in Solid Tumors
Time: 9:00 am
day: Day 2
Details:
- Enhancing safety by incorporating stearic masks into T cell engagers, minimizing systemic toxicity
- Leveraging protease-cleavable linkers that unmask and activate T cell engagers in the presence of tumor-specific proteases, enhancing targeted immune activation in solid tumors
- Optimizing tumor-specific activation to expand therapeutic index and minimize on-target, off-tumor effects of potent T cell engagers
