Strategies for Rapid Definition of Clinical Dose for T Cell-Engaging Therapies in Oncology
Time: 10:30 am
day: Day 1
Details:
- Implementing innovative dose-finding strategies, including model-informed drug development and adaptive trial designs, to accelerate dose selection for T-cell engages
- Optimizing the balance between efficacy and safety by leveraging pharmacokinetic/pharmacodynamic modeling, biomarkers, and real-time patient monitoring
- Refining dosing paradigms through insights from recent clinical trials, including step-up dosing, intra-patient escalation, and mitigation strategies for cytokine release syndrome
