Tackling T-Cell Exhaustion Through Co-Stimulation to Improve Response Durability & Control Immune Activation
Time: 9:30 am
day: Workshop A
Details:
Join this workshop to unlock the full potential of T-cell engagers through costimulation. As we look to enhance T-cell activation beyond the traditional CD3 signal, incorporating co-stimulatory signals into the TCR cascade could be a game-changer for potency and specificity. Key insights from second-gen CAR-T therapies, where co-stimulation played a pivotal role in approvals, are shaping new trispecific engages that simultaneously target tumor cells and co-stimulate T-cells. In this session, we’ll dive into how this approach is boosting cytokine release and refining the balance
between efficacy and toxicity.
Discussion Points:
- Integrating co-stimulation into the TCR signaling cascade to enhance T-cell activation
- Exploring trispecific T-cell engagers to co-stimulate and target tumors simultaneously
- Balancing cytokine release and potency by optimizing co-stimulatory signals for controlled immune activation
- Limiting cytokine release to only within the tumor
