Reviewing the Benefits of Using TCR Based Cell Engager Rather than an Antibody Based Cell Engager to Bind to MHC Over Epitopes
Time: 11:15 am
day: Day 2
Details:
- Assessing the advantages of TCR-based cell engagers in recognizing MHC-bound epitopes over antibody-based approaches, with improved specificity for tumorassociated antigens
- Enhancing T-cell activation by utilizing TCRs that recognize native, processed epitopes, minimizing reliance on antibody interactions and enhancing immune response precision
- Optimizing TCR-based engagers for solid tumor targeting, considering TCR affinity, tumor antigen presentation, and potential for reduced immune escape mechanisms
