Quantitative Systems Pharmacology Modeling to Facilitate Translations Between Bench & Bedside: Forward & Back & Branching Out
Time: 2:30 pm
day: Conference Day 1
Details:
- Quantitative systems pharmacology (QSP) modeling integrates in vitro data, in vivo PK and PD data, mechanism of action of the drug and biological understanding of the disease. I will demonstrate in my talk how QSP modeling is a powerful tool for translation to clinical as well as back translation from clinical to bench.
- For T cell engager first-in-human studies, we developed a QSP model that captures the CD3:drug:TAA cross-linking complex formation to support higher starting dose than an exposure-based MABEL approach. It has also been used to guide efficacious dose selection since bispecific molecules can have bell-shaped dose responses where a higher dose could lead to reduced efficacy.
- In addition to translation, QSP modeling can also be used early in R&D to guide novel platform design and perform in silico proof-of-concept simulations.
